{"id":622,"date":"2026-02-04T17:58:24","date_gmt":"2026-02-04T17:58:24","guid":{"rendered":"https:\/\/cromatografos-de-gases.com.mx\/blog\/?p=622"},"modified":"2026-02-04T18:53:49","modified_gmt":"2026-02-04T18:53:49","slug":"que-diferencias-existen-entre-un-hplc-y-un-uplc","status":"publish","type":"post","link":"https:\/\/cromatografos-de-gases.com.mx\/blog\/2026\/02\/que-diferencias-existen-entre-un-hplc-y-un-uplc\/","title":{"rendered":"\u00bfQu\u00e9 diferencias existen entre un HPLC y un UPLC?"},"content":{"rendered":"<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Tiempo de lectura:<\/span> <span class=\"rt-time\"> 3<\/span> <span class=\"rt-label rt-postfix\">minutos<\/span><\/span><p>[et_pb_section fb_built=\u00bb1&#8243; _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p style=\"text-align: justify;\">En la <a href=\"https:\/\/cromatografos-de-liquidos-hplc.com.mx\/otros-equipos\/cromatografia-de-liquidos\/22\" target=\"_blank\" rel=\"noopener\"><strong>cromatograf\u00eda de l\u00edquidos<\/strong><\/a> moderna, <strong>HPLC y UPLC<\/strong> son dos tecnolog\u00edas ampliamente utilizadas para la separaci\u00f3n, identificaci\u00f3n y cuantificaci\u00f3n de compuestos qu\u00edmicos. Aunque comparten el mismo principio cromatogr\u00e1fico, no son equivalentes ni intercambiables en todos los escenarios.<\/p>\n<p style=\"text-align: justify;\">Elegir correctamente entre <a href=\"https:\/\/cromatografos-de-liquidos-hplc.com.mx\/otros-equipos\/equipos-hplc\/21\" target=\"_blank\" rel=\"noopener\"><strong>equipos HPLC<\/strong> <\/a>y UPLC depende del tipo de muestra, los requerimientos de resoluci\u00f3n, la velocidad del an\u00e1lisis, el cumplimiento normativo y el costo total de operaci\u00f3n.<\/p>\n<p style=\"text-align: justify;\">En este art\u00edculo presentamos una comparativa t\u00e9cnica clara, con ventajas, limitaciones y casos de uso recomendados para cada tecnolog\u00eda.<\/p>\n<h2 style=\"text-align: justify;\"><strong>Principio general: lo que tienen en com\u00fan los equipos HPLC y los UPLC<\/strong><\/h2>\n<p>Tanto los<a href=\"https:\/\/cromatografos-de-liquidos-hplc.com.mx\/otros-equipos\/equipos-hplc\/21\" target=\"_blank\" rel=\"noopener\"> <strong>equipos HPLC<\/strong><\/a> como UPLC funcionan bajo el mismo fundamento:<\/p>\n<ul>\n<li>Separaci\u00f3n de compuestos mediante una fase estacionaria (columna).<\/li>\n<li>Transporte de la muestra por una fase m\u00f3vil l\u00edquida.<\/li>\n<li>Detecci\u00f3n mediante UV, PDA, RID, ELSD u otros detectores.<\/li>\n<li>Generaci\u00f3n de cromatogramas para identificaci\u00f3n y cuantificaci\u00f3n.<\/li>\n<\/ul>\n<p>La diferencia clave no est\u00e1 en el principio, sino en la forma en que se optimiza la separaci\u00f3n.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h2><strong>Diferencia t\u00e9cnica entre un equipo HPLC y un UPLC: tama\u00f1o de part\u00edcula y presi\u00f3n<\/strong><\/h2>\n<table border=\"1\" style=\"border-collapse: collapse; width: 100%; height: 152px;\">\n<tbody>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px; text-align: justify;\"><strong>Caracter\u00edstica<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 24px; text-align: justify;\"><strong>HPLC<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 24px; text-align: justify;\"><strong>UPLC<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 56px; text-align: justify;\">\n<td style=\"width: 33.3333%; height: 56px;\">Tama\u00f1o de part\u00edcula de columna<\/td>\n<td style=\"width: 33.3333%; height: 56px;\">3 \u2013 5 \u00b5m<\/td>\n<td style=\"width: 33.3333%; height: 56px;\">&lt; 2 \u00b5m (1.7 \u00b5m t\u00edpico)<\/td>\n<\/tr>\n<tr style=\"height: 24px; text-align: justify;\">\n<td style=\"width: 33.3333%; height: 24px;\">Presi\u00f3n de trabajo<\/td>\n<td style=\"width: 33.3333%; height: 24px;\">Hasta ~400 bar<\/td>\n<td style=\"width: 33.3333%;\">Hasta ~1,000\u20131,300 bar<\/td>\n<\/tr>\n<tr style=\"height: 24px; text-align: justify;\">\n<td style=\"width: 33.3333%; height: 24px;\">Velocidad de an\u00e1lisis<\/td>\n<td style=\"width: 33.3333%; height: 24px;\">Moderada<\/td>\n<td style=\"width: 33.3333%; height: 24px;\">Alta<\/td>\n<\/tr>\n<tr style=\"height: 24px; text-align: justify;\">\n<td style=\"width: 33.3333%; height: 24px;\">Resoluci\u00f3n<\/td>\n<td style=\"width: 33.3333%; height: 24px;\">Buena<\/td>\n<td style=\"width: 33.3333%; height: 24px;\">Muy alta<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify;\">UPLC utiliza part\u00edculas mucho m\u00e1s peque\u00f1as, lo que permite:<\/p>\n<ul style=\"text-align: justify;\">\n<li>Mayor eficiencia cromatogr\u00e1fica.<\/li>\n<li>Mejor separaci\u00f3n de picos cercanos.<\/li>\n<li>An\u00e1lisis m\u00e1s r\u00e1pidos.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">Esto exige sistemas mec\u00e1nicamente m\u00e1s robustos, capaces de trabajar a presiones mucho m\u00e1s elevadas.<\/p>\n<h2 style=\"text-align: justify;\"><strong>Resoluci\u00f3n y sensibilidad<\/strong><\/h2>\n<p><strong>HPLC<\/strong><\/p>\n<p>-Resoluci\u00f3n suficiente para:<\/p>\n<ul>\n<li>Control de calidad rutinario.<\/li>\n<li>M\u00e9todos normados tradicionales.<\/li>\n<li>An\u00e1lisis con matrices relativamente simples.<\/li>\n<\/ul>\n<p>-Ideal cuando:<\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>El m\u00e9todo ya est\u00e1 validado.<\/li>\n<li>La separaci\u00f3n es clara y estable.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong>UPLC<\/strong><\/p>\n<p>-Resoluci\u00f3n superior para:<\/p>\n<ul>\n<li>Impurezas relacionadas.<\/li>\n<li>Estudios de degradaci\u00f3n.<\/li>\n<li>Mezclas complejas o picos coeluyentes.<\/li>\n<\/ul>\n<p>-Permite:<\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Detectar compuestos que en <a href=\"https:\/\/cromatografos-de-liquidos-hplc.com.mx\/inicio\" target=\"_blank\" rel=\"noopener\"><strong>cromat\u00f3grafos de l\u00edquidos<\/strong> <\/a>aparecen solapados.<\/li>\n<li>Mejorar LOD\/LOQ en muchos m\u00e9todos.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_button button_url=\u00bbhttps:\/\/cromatografos-de-liquidos-hplc.com.mx\/contacto\u00bb url_new_window=\u00bbon\u00bb button_text=\u00bbHPLC vs UPLC: elige la tecnolog\u00eda correcta seg\u00fan tu muestra, tu m\u00e9todo y el nivel de resoluci\u00f3n que exige tu an\u00e1lisis. En Solinsa te asesoramos\u00bb button_alignment=\u00bbcenter\u00bb _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb custom_button=\u00bbon\u00bb button_icon_color=\u00bb#FCB51A\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h2 style=\"text-align: justify;\"><strong>Tiempo de an\u00e1lisis y productividad<\/strong><\/h2>\n<p><strong><\/strong><\/p>\n<table border=\"1\" style=\"border-collapse: collapse; width: 100%; height: 128px;\">\n<tbody>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px;\"><strong>Aspecto<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><strong>HPLC<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><strong>UPLC<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 56px;\">\n<td style=\"width: 33.3333%; height: 56px;\">Tiempo t\u00edpico de corrida<\/td>\n<td style=\"width: 33.3333%; height: 56px;\">15\u201345 min<\/td>\n<td style=\"width: 33.3333%; height: 56px;\">3\u201315 min<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px;\">Consumo de solvente<\/td>\n<td style=\"width: 33.3333%; height: 24px;\">Mayor<\/td>\n<td style=\"width: 33.3333%; height: 24px;\">Menor<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px;\">Capacidad de muestras\/d\u00eda<\/td>\n<td style=\"width: 33.3333%; height: 24px;\">Media<\/td>\n<td style=\"width: 33.3333%; height: 24px;\">Alta<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify;\">[\/et_pb_text][et_pb_text _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p style=\"text-align: justify;\">El equipo UPLC es ideal para laboratorios con alta carga anal\u00edtica, donde el tiempo y el consumo de solventes impactan directamente en costos y productividad.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h2><strong>Costos: equipo, columnas y operaci\u00f3n de los equipos HPLC y los UPLC<\/strong><\/h2>\n<table border=\"1\" style=\"border-collapse: collapse; width: 88.8026%; height: 246px;\">\n<tbody>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px; text-align: justify;\"><strong>Factor<\/strong><\/td>\n<td style=\"width: 33.3333%; height: 24px; text-align: justify;\"><strong>HPCL<\/strong><\/td>\n<td style=\"width: 1.10865%; height: 24px; text-align: justify;\"><strong>UPLC<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 56px;\">\n<td style=\"width: 33.3333%; height: 56px; text-align: left;\">Inversi\u00f3n inicial<\/td>\n<td style=\"width: 33.3333%; height: 56px; text-align: left;\">Menor<\/td>\n<td style=\"width: 1.10865%; height: 56px; text-align: left;\">Mayor<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px; text-align: left;\">Costo de columnas<\/td>\n<td style=\"width: 33.3333%; height: 24px; text-align: left;\">Menor<\/td>\n<td style=\"width: 1.10865%; height: 24px; text-align: left;\">M\u00e1s alto<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px; text-align: left;\">Consumo de solventes<\/td>\n<td style=\"width: 33.3333%; height: 24px; text-align: left;\">Mayor<\/td>\n<td style=\"width: 1.10865%; height: 24px; text-align: left;\">Menor<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px; text-align: left;\">Costo total a largo plazo<\/td>\n<td style=\"width: 33.3333%; height: 24px; text-align: left;\">Estable<\/td>\n<td style=\"width: 1.10865%; height: 24px; text-align: left;\">Puede optimizarse con alta productividad<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h2><strong>Casos de uso recomendados en tecnolog\u00edas de cromatograf\u00eda l\u00edquida <\/strong><\/h2>\n<p style=\"text-align: justify;\"><strong>\u00bfCu\u00e1ndo elegir HPLC?<\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li>Tequila y bebidas alcoh\u00f3licas:<\/li>\n<ul>\n<li>Az\u00facares, furfural, extracto seco.<\/li>\n<\/ul>\n<li>Alimentos y bebidas:<\/li>\n<ul>\n<li>Vitaminas, conservadores, dulzantes.<\/li>\n<\/ul>\n<li>Control de calidad rutinario.<\/li>\n<li>Laboratorios con enfoque normativo estricto.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong>\u00bfCu\u00e1ndo elegir UPLC?<\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li>Farma I+D y validaci\u00f3n:<\/li>\n<ul>\n<li>Impurezas relacionadas (ICH Q3).<\/li>\n<li>Estudios de estabilidad (ICH Q1).<\/li>\n<\/ul>\n<li>An\u00e1lisis complejos:<\/li>\n<ul>\n<li>Polifenoles, metabolitos, compuestos estructuralmente similares.<\/li>\n<\/ul>\n<li>Laboratorios con alta carga de muestras y necesidad de rapidez.<\/li>\n<\/ul>\n<ul>\n<li style=\"text-align: justify;\">Adaptarse al crecimiento del laboratorio.<\/li>\n<\/ul>\n<h2 style=\"text-align: justify;\"><strong>No es \u201cmejor o peor\u201d, es \u201cadecuado o no\u201d<\/strong><\/h2>\n<p style=\"text-align: justify;\">La elecci\u00f3n entre un <a href=\"https:\/\/cromatografos-de-liquidos-hplc.com.mx\/otros-equipos\/cromatografo-de-liquidos-de-alta-resolucion\/20\" target=\"_blank\" rel=\"noopener\"><strong>cromat\u00f3grafo de l\u00edquidos de alta resoluci\u00f3n<\/strong><\/a> entre equipos HPLC y UPLC no debe basarse solo en tecnolog\u00eda, sino en:<\/p>\n<ul style=\"text-align: justify;\">\n<li>Tipo de muestra.<\/li>\n<li>Complejidad del an\u00e1lisis.<\/li>\n<li>Requerimientos de resoluci\u00f3n.<\/li>\n<li>Volumen de trabajo.<\/li>\n<li>Presupuesto y cumplimiento regulatorio.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">En <strong>Solinsa<\/strong> ayudamos a evaluar tu aplicaci\u00f3n real, no solo el equipo, para definir la tecnolog\u00eda que mejor se adapta a tus necesidades anal\u00edticas, normativas y operativas. <a href=\"https:\/\/cromatografos-de-liquidos-hplc.com.mx\/contacto\" target=\"_blank\" rel=\"noopener\"><strong>Solicita asesor\u00eda aqu\u00ed.<\/strong><\/a><\/p>\n<p>[\/et_pb_text][et_pb_testimonial author=\u00bbSolinsa\u00bb portrait_url=\u00bbhttps:\/\/cromatografos-de-gases.com.mx\/blog\/wp-content\/uploads\/2026\/02\/Beneficios-recomend.jpg\u00bb _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb sticky_enabled=\u00bb0&#8243;]<\/p>\n<p><strong>Te recomendamos la siguiente lectura:<\/strong><\/p>\n<p class=\"entry-title\" id=\"BeneficiosoperativosdelmantenimientopreventivoenHPLCGCeIC\"><span style=\"color: #3366ff;\"><strong><a href=\"https:\/\/cromatografos-de-gases.com.mx\/blog\/2025\/08\/beneficios-operativos-del-mantenimiento-preventivo-en-hplc-gc-e-ic\/\" target=\"_blank\" rel=\"noopener\" style=\"color: #3366ff;\">Beneficios operativos del mantenimiento preventivo en HPLC, GC e IC<\/a><\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_testimonial][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Tiempo de lectura:<\/span> <span class=\"rt-time\"> 3<\/span> <span class=\"rt-label rt-postfix\">minutos<\/span><\/span>Comparativa t\u00e9cnica entre HPLC y UPLC: conoce sus diferencias, ventajas, limitaciones y casos de uso seg\u00fan el tipo de muestra, resoluci\u00f3n requerida y necesidades del laboratorio.<\/p>\n","protected":false},"author":2,"featured_media":623,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[1,71],"tags":[102,106,104,103,57,36,105],"class_list":["post-622","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cromatografos","category-cromatografos-de-gases","tag-cromatografia-de-liquidos","tag-cromatografo-de-liquidos","tag-cromatografo-de-liquidos-de-alta-resolucion","tag-cromatografos-liquidos","tag-equipos-hplc-2","tag-hplc","tag-uplc"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.10 - aioseo.com -->\n\t<meta name=\"description\" content=\"Comparativa t\u00e9cnica entre HPLC y UPLC: conoce sus diferencias, ventajas, limitaciones y casos\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Contenido\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/cromatografos-de-gases.com.mx\/blog\/2026\/02\/que-diferencias-existen-entre-un-hplc-y-un-uplc\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.10\" \/>\n\t\t<meta property=\"og:locale\" content=\"es_ES\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Blog cromat\u00f3grafo de gases - En Solinsa tenemos venta de cromat\u00f3grafos de gases reacondicionados y de medio uso para ofrecerte precios bajos. 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